2002/03/05 by Christophe Hardouin, Eric Doris, Bernard Rousseau +1 · 3 citations
Pharmacology, Toxicology and Pharmaceutics · Chemistry · #Fluorine in Organic Chemistry #Radical Photochemical Reactions #Alkaloids: synthesis and pharmacology
paper · doi:10.1021/ol025560c
openalex publication_date 2002/03/05 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/22
[reaction: see text] The Cp(2)TiCl-mediated deoxygenation of leurosine (1) afforded anhydrovinblastine (4) in good yield. Furthermore, as the reaction proceeded via a carbon-centered radical intermediate, this transient was also trapped by a hydrogen-atom donor to afford selectively reduced alkaloid 10.