2008/12/03 by Andreas Hoeflich, Maximilian Bielohuby · 1 citation
Medicine · Neuroscience · #Adipose Tissue and Metabolism #Adrenal cortex #Adrenal gland #Angiotensin II #Biology #Cell biology #Circadian rhythm and melatonin #Effector #Endocrine system #Endocrinology #Endogeny #Extracellular #Homeostasis #Hormonal Regulation and Hypertension #Hormone #Internal medicine #Medicine #Pituitary gland #Signal transduction
paper · pdf · doi:10.1677/jme-08-0160
openalex publication_date 2008/12/03 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/21
The adrenal gland influences a multitude of processes during stress response, but also potently affects the immune system, glucose metabolism, electrolyte or water homeostasis, and cardiovascular functions. According to the present understanding, the adrenal cortex is tightly controlled by the hypothalamic-pituitary-adrenal axis. This axis involves hypothalamic CRH and pituitary ACTH which determine processes of adrenocortical growth and function. However, control of the adrenal gland comprises a plethora of additional endogenous or exogenous factors. Among those are diverse hormones, psychosocial parameters, physiological stress, secondary plant products, or even environmental pollutants. In the present review, we summarize the current view of endocrine growth control in the adrenal gland. We then discuss intracellular mechanisms of adrenal growth control and focus on extracellular signal regulated kinases 1/2 (ERK1/2), which have been demonstrated to be controlled by not only ACTH or angiotensin II, but also by a large number of additional effectors. On the basis of these multiple exogenous or endogenous factors which impact on the adrenal gland through ERK1/2 activity, we speculate on a mechanism by which ERK1/2 act as a central integrative growth regulatory elements in the adrenal gland.