2012/05/18 by Péter Keglevich, László Hazai, György Kalaus +1 · 3 citations
Medicine · Pharmacology, Toxicology and Pharmaceutics · Chemistry · #Cancer Treatment and Pharmacology #Alkaloids: synthesis and pharmacology #Chemical synthesis and alkaloids
paper · pdf · doi:10.3390/molecules17055893
openalex publication_date 2012/05/18 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
The synthetic investigation of biologically active natural compounds serves two main purposes: (i) the total synthesis of alkaloids and their analogues; (ii) modification of the structures for producing more selective, more effective, or less toxic derivatives. In the chemistry of dimeric Vinca alkaloids enormous efforts have been directed towards synthesizing new derivatives of the antitumor agents vinblastine and vincristine so as to obtain novel compounds with improved therapeutic properties.