1942/12/01 by Charles H. Rammelkamp, T. Maxon · 6 citations
Medicine · #Antimicrobial Resistance in Staphylococcus #Historical Medical Research and Treatments
paper · doi:10.3181/00379727-51-13986
openalex publication_date 1942/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/23
Strains of Staphylococcus aureus vary only slightly in their susceptibility to the antibacterial action of penicillin. By growing the organism in increasing concentrations of penicillin over a long period it was possible to render the organism resistant to penicillin. Similar degrees of increased resistance were found in 4 strains of staphylococci isolated during the course of penicillin therapy for localized infections.