2017/08/08 by Özden Baltekin, Alexis Boucharin, Eva Tano +2 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Bacterial Identification and Susceptibility Testing #Urinary Tract Infections Management #Gut microbiota and health
paper · pdf · doi:10.1073/pnas.1708558114
openalex publication_date 2017/08/08 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
Significance Antibiotic resistance is a global threat to human health. The problem is aggravated by unnecessary and incorrect use of broad spectrum antibiotics. One way to provide correct treatment and slow down the development of antibiotic resistance is to assay the susceptibility profile of the infecting bacteria before treatment is initiated and let this information guide the choice of antibiotic. Here, we present an antibiotic susceptibility test that is sufficiently fast to be used at the point of care. We show that it is possible to determine if a urinary tract infection is caused by resistant bacteria within 30 min of loading a urine sample, even if the bacterial concentration in the urine is very low.