2006/02/15 by Victor J. Navarro, John Senior · 2 citations
Pharmacology, Toxicology and Pharmaceutics · Medicine · #Drug-Induced Hepatotoxicity and Protection #Pharmacogenetics and Drug Metabolism #Drug Transport and Resistance Mechanisms
paper · doi:10.1056/nejmra052270
openalex publication_date 2006/02/15 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Given its rarity, drug-related hepatotoxicity may not be seen during the initial clinical trials of a new medication. After approval, when many more patients are exposed, toxic effects that are very infrequent may emerge. This review explains the difficulties in identifying the cause of hepatotoxic effects in such situations and provides clinical guidance with regard to the detection, evaluation, and possible prevention of drug-related hepatotoxicity.