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On the Polymorphism of Aspirin: Crystalline Aspirin as Intergrowths of Two “Polymorphic” Domains

2006/12/01 by Andrew D. Bond, Roland Boese, Gautam R. Desiraju · 2 citations
Chemistry · #Crystallography and molecular interactions #Crystal structures of chemical compounds #Synthesis of β-Lactam Compounds

paper · doi:10.1002/anie.200603373

openalex publication_date 2006/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Aspirin: No end to the headaches? The two known crystalline arrangements of aspirin are so closely related that aspirin crystals form intergrowth structures containing domains of form I and domains of form II. The ratio and distribution of the domains is variable among aspirin samples, raising questions for the definition of the term polymorph in this case.

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