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First case report of acute hemorrhagic leukoencephalitis following Plasmodium vivax infection

2013/01/01 by Vasantha Kumar Venugopal, Mehvash Haider · 1 citation
Medicine · Biochemistry, Genetics and Molecular Biology · #Infectious Encephalopathies and Encephalitis #Mosquito-borne diseases and control #Yersinia bacterium, plague, ectoparasites research

paper · pdf · doi:10.4103/0255-0857.108736

openalex publication_date 2013/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Abstract

Acute hemorrhagic leukoencephalitis (AHLE, Hurst's disease) is a rare hyperacute variant of acute disseminated encephalomyelitis (ADEM) characterized by severe, rapidly progressive clinical illness and hemorrhagic necrosis of white matter. Like ADEM, it is often preceded by viral illness or vaccination. Plasmodium vivax infection is usually uncomplicated and non-fatal with only a handful of reports of central nervous system complications. In this article, we report a previously unknown association between AHLE and P. vivax infection.

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