2015/03/31 by Hiroshi Mitoma, Keya Adhikari, Daniel Aeschlimann +14 · 6 citations
Medicine · Neuroscience · Biochemistry, Genetics and Molecular Biology · #Autoimmune Neurological Disorders and Treatments #Genetic Neurodegenerative Diseases #RNA regulation and disease
paper · pdf · doi:10.1007/s12311-015-0664-x
openalex publication_date 2015/03/31 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
In the last few years, a lot of publications suggested that disabling cerebellar ataxias may develop through immune-mediated mechanisms. In this consensus paper, we discuss the clinical features of the main described immune-mediated cerebellar ataxias and address their presumed pathogenesis. Immune-mediated cerebellar ataxias include cerebellar ataxia associated with anti-GAD antibodies, the cerebellar type of Hashimoto's encephalopathy, primary autoimmune cerebellar ataxia, gluten ataxia, Miller Fisher syndrome, ataxia associated with systemic lupus erythematosus, and paraneoplastic cerebellar degeneration. Humoral mechanisms, cell-mediated immunity, inflammation, and vascular injuries contribute to the cerebellar deficits in immune-mediated cerebellar ataxias.