2008/12/17 by Ethan M. Goldberg, Douglas A. Coulter, N. Fettal +2 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · #Diagnosis and treatment of tuberculosis #Epilepsy research and treatment #Mitochondrial Function and Pathology #Neuroscience and Neuropharmacology Research #Pneumocystis jirovecii pneumonia detection and treatment #Tuberculosis Research and Epidemiology
paper · doi:10.1038/nrn3482
openalex publication_date 2013/04/18 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/01
Epilepsy is a prevalent neurological disorder associated with significant morbidity and mortality, but the only available drug therapies target its symptoms rather than the underlying cause. The process that links brain injury or other predisposing factors to the subsequent emergence of epilepsy is termed epileptogenesis. Substantial research has focused on elucidating the mechanisms of epileptogenesis so as to identify more specific targets for intervention, with the hope of preventing epilepsy before seizures emerge. Recent work has yielded important conceptual advances in this field. We suggest that such insights into the mechanisms of epileptogenesis converge at the level of cortical circuit dysfunction.