2014/05/13 by Gye-Hong Kim, Kwon-Soo Chun, Sung Ho Park +1 · 2 citations
Chemistry · Medicine · Physics and Astronomy · #Atomic physics #Beam (structure) #Bismuth #Boron Compounds in Chemistry #Chemistry #Cyclotron #Irradiation #Linear energy transfer #Materials science #Nuclear Physics and Applications #Nuclear physics #Optics #Physics #Radiochemistry #Radionuclide #Radiopharmaceutical Chemistry and Applications #Range (aeronautics)
paper · doi:10.1088/0031-9155/59/11/2849
openalex publication_date 2014/05/13 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/30
Among the α-particle emitting radionuclides, (211)At is considered to be a promising radionuclide for targeted cancer therapy due to its decay properties. The range of alpha particles produced by the decay of (211)At are less than 70 µm in water with a linear energy transfer between 100 and 130 keV µm(-1), which are about the maximum relative biological effectiveness for heavy ions. It is important to note that at the present time, only a few of cyclotrons routinely produce (211)At. The direct production method is based on the nuclear reactions (209)Bi(α,2n)(211)At. Production of the radionuclide (211)At was carried out using the MC-50 cyclotron at the Korea Institute of Radiological and Medical Sciences (KIRAMS). To ensure high beam current, the α-beam was extracted with an initial energy of 45 MeV, which was degraded to obtain the appropriate α-beam energy. The calculations of beam energy degradation were performed utilizing the MCNPX. Alumina-baked targets were prepared by heating the bismuth metal powder onto a circular cavity in a furnace. When using an E(α, av) of 29.17 MeV, the very small contribution of (210)At confirms the right choice of the irradiation energy to obtain a pure production of (211)At isotope.