2022/01/01 by Hany Akeel Al-Hussaniy, Haedar A.AL-Biati · 1 citation
Neuroscience · Medicine · #Regulation of Appetite and Obesity #Adipose Tissue and Metabolism #Adipokines, Inflammation, and Metabolic Diseases
paper · pdf · doi:10.55940/medphar20227
openalex publication_date 2022/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/26
In addition to energy storage, the adipose tissue plays multiple important roles, particularly the secretion of biomolecules such as leptin that participate in the neuroendocrine regulation of appetite. Therefore, this review sought to understand the influence of leptin on the genesis of obesity. A systemic review of the literature was conducted using articles published in English between 2016 and 2022. Ten experimental studies that introduced new approaches for treating leptin-resistant individuals were selected. The results showed that a structured food plan with a negative energy balance combined with a regular physical activity routine remains the best way to combat obesity and leptin resistance problems. It is possible to conclude that leptin resistance contributes to maintaining obesity. However, to date, there remains a lack of evidence that demonstrates a direct relationship between the poor function of this peptide and the genesis of obesity.