2010/10/26 by David D. L. Minh, John D. Chodera
Biochemistry, Genetics and Molecular Biology · Physics and Astronomy · #Advanced Fluorescence Microscopy Techniques #Advanced Thermodynamics and Statistical Mechanics #Estimator #Force Microscopy Techniques and Applications #Metric (unit) #Non-equilibrium thermodynamics #Pooling #Process (computing) #Statistical mechanics #Variance (accounting) #cond-mat.stat-mech
paper · pdf · doi:10.1063/1.3516517
published as J. Chem. Phys. 134:024111 (2011) · 28 pages, 9 figures
arxiv created 2010/10/26 · openalex publication_date 2011/01/12 · arxiv updated 2011/11/21 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/05
Recently discovered identities in statistical mechanics have enabled the calculation of equilibrium ensemble averages from realizations of driven nonequilibrium processes, including single-molecule pulling experiments and analogous computer simulations. Challenges in collecting large data sets motivate the pursuit of efficient statistical estimators that maximize use of available information. Along these lines, Hummer and Szabo developed an estimator that combines data from multiple time slices along a driven nonequilibrium process to compute the potential of mean force. Here, we generalize their approach, pooling information from multiple time slices to estimate arbitrary equilibrium expectations. Our expression may be combined with estimators of path-ensemble averages, including existing optimal estimators that use data collected by unidirectional and bidirectional protocols. We demonstrate the estimator by calculating free energies, moments of the polymer extension, the thermodynamic metric tensor, and the thermodynamic length in a model single-molecule pulling experiment. Compared to estimators that only use individual time slices, our multiple time-slice estimators yield substantially smoother estimates and achieve lower variance for higher-order moments.