2011/09/27 by Changbong Hyeon, D. Thirumalai · 2 citations
Biochemistry, Genetics and Molecular Biology · Physics and Astronomy · #DNA and Nucleic Acid Chemistry #Genomics and Chromatin Dynamics #RNA and protein synthesis mechanisms #cond-mat.soft #physics.bio-ph #q-bio.BM
paper · pdf · doi:10.1038/ncomms1481
published as Nature Communications (2011) 2:487 · 37 pages, 8 figures
arxiv created 2011/09/27 · openalex publication_date 2011/09/27 · arxiv updated 2011/09/28 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29
The distances over which biological molecules and their complexes can function range from a few nanometres, in the case of folded structures, to millimetres, for example during chromosome organization. Describing phenomena that cover such diverse length, and also time scales, requires models that capture the underlying physics for the particular length scale of interest. Theoretical ideas, in particular, concepts from polymer physics, have guided the development of coarse-grained models to study folding of DNA, RNA, and proteins. More recently, such models and their variants have been applied to the functions of biological nanomachines. Simulations using coarse-grained models are now poised to address a wide range of problems in biology.