2013/11/19 by Lukáš Jedinák, LaToya Rush, Mijoon Lee +5 · 1 citation
Chemistry · #Organophosphorus compounds synthesis #Phosphorus compounds and reactions #Synthesis and Reactivity of Sulfur-Containing Compounds
paper · doi:10.1021/jo401972a
openalex publication_date 2013/11/19 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
An efficient synthesis of olefins by the coupling of stabilized, semistabilized, and nonstabilized phosphorus ylides with various carbonyl compounds in the presence of silver carbonate is reported. Wittig olefination of aromatic, heteroaromatic, and aliphatic aldehydes (yields >63%) and a ketone (yield 42%) are demonstrated. These reactions proceed overnight at room temperature, under weakly basic conditions, and as such extend the applicability of the Wittig reaction to base-sensitive reactants.