2014/08/21 by Kuti Baruch, Aleksandra Deczkowska, Eyal David +9 · 1 citation
Neuroscience · Immunology and Microbiology · #Neuroinflammation and Neurodegeneration Mechanisms #interferon and immune responses #Immune Response and Inflammation
paper · doi:10.1126/science.1252945
openalex publication_date 2014/08/21 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/01
Aging-associated cognitive decline is affected by factors produced inside and outside the brain. By using multiorgan genome-wide analysis of aged mice, we found that the choroid plexus, an interface between the brain and the circulation, shows a type I interferon (IFN-I)-dependent gene expression profile that was also found in aged human brains. In aged mice, this response was induced by brain-derived signals, present in the cerebrospinal fluid. Blocking IFN-I signaling within the aged brain partially restored cognitive function and hippocampal neurogenesis and reestablished IFN-II-dependent choroid plexus activity, which is lost in aging. Our data identify a chronic aging-induced IFN-I signature, often associated with antiviral response, at the brain's choroid plexus and demonstrate its negative influence on brain function, thereby suggesting a target for ameliorating cognitive decline in aging.