Simple evolutionary pathways to complex proteins

2005/08/30 by Michael Lynch · 4 citations
Biochemistry, Genetics and Molecular Biology · #Evolution and Genetic Dynamics #Bioinformatics and Genomic Networks #Protein Structure and Dynamics

paper · pdf · doi:10.1110/ps.041171805

openalex publication_date 2005/08/30 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

A recent paper in this journal has challenged the idea that complex adaptive features of proteins can be explained by known molecular, genetic, and evolutionary mechanisms. It is shown here that the conclusions of this prior work are an artifact of unwarranted biological assumptions, inappropriate mathematical modeling, and faulty logic. Numerous simple pathways exist by which adaptive multi-residue functions can evolve on time scales of a million years (or much less) in populations of only moderate size. Thus, the classical evolutionary trajectory of descent with modification is adequate to explain the diversification of protein functions.

Citations

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• High mutation rate and predominance of insertions in the Caenorhabditis elegans nuclear genome
• The Neutral Theory of Molecular Evolution

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