1982/05/01 by Mary Ann Werz, Robert L. Macdonald, 誠 金森 +3 · 2 citations
Agricultural and Biological Sciences · Medicine · Neuroscience · #Cephalopods and Marine Biology #Neurobiology and Insect Physiology Research #Neuropeptides and Animal Physiology #Pain Mechanisms and Treatments
paper · doi:10.1016/0006-8993(82)90859-9
crossref issued 1982/05/01 · crossref published 1982/05/01 · crossref published-print 1982/05/01 · crossref created 2003/04/24 · openalex publication_date 2014/01/01 · openalex created_date 2016/06/24 · crossref deposited 2019/03/23 · crossref indexed 2026/02/20 · openalex updated_date 2026/06/11
We investigated opioid peptide actions on somatic calcium-dependent action potentials of dorsal root ganglion (DRG) neurons grown in primary dissociated cell culture. We report that leucine-enkephalin decreased the duration and amplitude of DRG somatic calcium-dependent action potentials. The opioid peptide action was dose-dependent over 20 nM to 5 microM and was antagonized by naloxone, consistent with mediation by opiate receptors. Thus, DRG neuron membranes have opiate receptors which act to decrease calcium influx. It is more likely, therefore, that opiate receptors on the somata of DRG neurons in culture are functionally similar to opiate receptors on primary afferent terminals.