2007/12/01 by Sherise D. Ferguson, Kimberly A. Foster, Bakhtiar Yamini · 1 citation
Medicine · Materials Science · Neuroscience · #Glioma Diagnosis and Treatment #Nanoparticle-Based Drug Delivery #Neuroscience and Neural Engineering
paper · doi:10.1586/14737140.7.12s.s79
openalex publication_date 2007/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29
Recently, innovative therapies have been developed for the treatment of malignant gliomas. Unfortunately, adequate delivery of these therapies has been a major obstacle to clinical success. Intravenous administration is restricted by the presence of the blood-brain barrier while local delivery, such as with drug-impregnated wafers, results in limited parenchyma penetration. Convection-enhanced delivery is a promising method for the delivery of macromolecules to the CNS. Convection-enhanced delivery involves the infusion of therapeutic agents via surgically implanted catheters and uses a pressure gradient to achieve a greater volume of distribution compared with that seen with diffusion alone. This article will review the development of convection-enhanced delivery and its use in the treatment of malignant gliomas.