2021/07/26 by Hyoung Kyu Kim, Е. А. Васильева, Natalia P. Mishchenko +2 · 1 citation
Pharmacology, Toxicology and Pharmaceutics · Chemistry · Agricultural and Biological Sciences · #Bioactive Compounds and Antitumor Agents #Synthesis of heterocyclic compounds #Echinoderm biology and ecology
paper · pdf · doi:10.3390/md19080412
openalex publication_date 2021/07/26 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
The marine drug histochrome is a special natural antioxidant. The active substance of the drug is echinochrome A (Ech A, 7-ethyl-2,3,5,6,8-pentahydroxy-1,4-naphthoquinone), the most abundant quinonoid pigment in sea urchins. The medicine is clinically used in cardiology and ophthalmology based on the unique properties of Ech A, which simultaneously block various links of free radical reactions. In the last decade, numerous studies have demonstrated the effectiveness of histochrome in various disease models without adverse effects. Here, we review the data on the various clinical effects and modes of action of Ech A in ophthalmic, cardiovascular, cerebrovascular, inflammatory, metabolic, and malignant diseases.