Why the honey badger don't care: Convergent evolution of venom-targeted nicotinic acetylcholine receptors in mammals that survive venomous snake bites

2015/03/25 by Danielle H. Drabeck, Antony M. Dean, Sharon A. Jansa · 1 voice · 24 citations
Biochemistry, Genetics and Molecular Biology · Agricultural and Biological Sciences · #Nicotinic Acetylcholine Receptors Study #Venomous Animal Envenomation and Studies #Insect and Pesticide Research

paper · doi:10.1016/j.toxicon.2015.03.007

Citations

• Multigene phylogeny of the Mustelidae: Resolving relationships, tempo and biogeographic history of a mammalian adaptive radiation

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• Comparison of Strategies to Overcome Drug Resistance: Learning from Various Kingdoms. [europepmc]
• Structure of the Native Muscle-type Nicotinic Receptor and Inhibition by Snake Venom Toxins. [europepmc]
• Epidemiology, Clinical Features, and Management of Texas Coral Snake (Micrurus tener) Envenomations Reported to the North American Snakebite Registry. [europepmc]
• Physiological Stress Integrates Resistance to Rattlesnake Venom and the Onset of Risky Foraging in California Ground Squirrels. [europepmc]
• Widespread Evolution of Molecular Resistance to Snake Venom α-Neurotoxins in Vertebrates. [europepmc]
• Assessing the Binding of Venoms from Aquatic Elapids to the Nicotinic Acetylcholine Receptor Orthosteric Site of Different Prey Models. [europepmc]
• Electrostatic resistance to alpha-neurotoxins conferred by charge reversal mutations in nicotinic acetylcholine receptors. [europepmc]
• Mutual enlightenment: A toolbox of concepts and methods for integrating evolutionary and clinical toxinology via snake venomics and the contextual stance. [europepmc]
• Rattlesnake envenomation in 2 Visayan warty pigs. [europepmc]
• Molecular game theory for a toxin-dominant food chain model. [europepmc]
• Monkeying around with venom: an increased resistance to α-neurotoxins supports an evolutionary arms race between Afro-Asian primates and sympatric cobras. [europepmc]
• Convergent evolution of toxin resistance in animals. [europepmc]
• The roles of balancing selection and recombination in the evolution of rattlesnake venom. [europepmc]
• Preying dangerously: black widow spider venom resistance in sympatric lizards. [europepmc]
• Widespread convergent evolution of alpha-neurotoxin resistance in African mammals. [europepmc]
• Venom biotechnology: casting light on nature's deadliest weapons using synthetic biology. [europepmc]
• A Russian Doll of Resistance: Nested Gains and Losses of Venom Immunity in Varanid Lizards. [europepmc]
• High-Voltage Toxin'Roll: Electrostatic Charge Repulsion as a Dynamic Venom Resistance Trait in Pythonid Snakes. [europepmc]
• Red-on-Yellow Queen: Bio-Layer Interferometry Reveals Functional Diversity Within Micrurus Venoms and Toxin Resistance in Prey Species. [europepmc]
• Extraordinary variance in meta-analysis of venom toxicity of 160 most lethal ophidians and guidelines for estimating human lethal dose range. [europepmc]
• Make Acetylcholine Great Again! Australian Skinks Evolved Multiple Neurotoxin-Proof Nicotinic Acetylcholine Receptors in Defiance of Snake Venom. [europepmc]
• Venom Variation as a Window into the Ecology and Evolution of Snakes. [europepmc]

Discussions

• The honey badger isn’t the only species to evolve resistance to neurotoxins from venomous snakes - other species have convergently (independently) evolved similar genetic resistance mechanisms. doi.or [bsky, 19 points, 0 comments]