2011/03/02 by Gérard Karsenty, Franck Oury · 1 citation
Neuroscience · Medicine · #Regulation of Appetite and Obesity #Adipose Tissue and Metabolism #Growth Hormone and Insulin-like Growth Factors
paper · doi:10.1146/annurev-physiol-020911-153233
openalex publication_date 2011/03/02 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
Classical studies of vertebrate physiology have usually been confined to a given organ or cell type. The use of mouse genetics has changed this approach and has rejuvenated the concept of a whole-body study of physiology. One physiological system that has been profoundly influenced by mouse genetics is skeletal physiology. Indeed, genetic approaches have identified several unexpected organs that affect bone physiology. These new links have begun to provide a plausible explanation for the evolutionary involvement of hormones such as leptin with bone physiology. These genetic approaches have also revealed bone as a true endocrine organ capable of regulating energy metabolism and reproduction. Collectively, the body of work discussed below illustrates a new and unconventional role for bone in mammalian physiology.