2000/09/01 by Michael E. Zwick, David J. Cutler, Aravinda Chakravarti · 1 citation
Biochemistry, Genetics and Molecular Biology · #Genetic Mapping and Diversity in Plants and Animals #Genetic Associations and Epidemiology #Genetic and phenotypic traits in livestock
paper · doi:10.1146/annurev.genom.1.1.387
openalex publication_date 2000/09/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/22
This review discusses the prospects for understanding the genetic basis of complex traits in humans. We take the view that work done on Drosophila melanogaster can serve as a model for understanding complex traits in humans, and the literature on this model system, as well as on humans, is reviewed. The prospects for success in understanding the genetic basis of complex traits depend, in part, on the nature of the forces acting on genetic variation. We suggest that different experimental approaches should be undertaken for traits caused by common genetic variants versus those arising from rare genetic variants.