2008/04/01 by Sinéad M. Ryan, Giuseppe Mantovani, Xuexuan Wang +2 · 1 citation
Biochemistry, Genetics and Molecular Biology · Materials Science · #RNA Interference and Gene Delivery #Dendrimers and Hyperbranched Polymers #Nanoparticle-Based Drug Delivery
paper · doi:10.1517/17425247.5.4.371
openalex publication_date 2008/04/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
BACKGROUND: Although various injected peptide and protein therapeutics have been developed successfully over the past 25 years, several pharmacokinetic and immunological challenges are still encountered that can limit the efficacy of both novel and established biotech molecules. OBJECTIVE AND METHOD: PEGylation is a popular technique to address such properties. PEGylated drugs exhibit prolonged half-life, higher stability, water solubility, lower immunogenicity and antigenicity, as well as potential for specific cell targeting. Although PEGylated drug conjugates have been on the market for many years, the technology has steadily developed in respect of site-specific chemistry, chain length, molecular weights and purity of conjugate. These developments have occurred in parallel to improvements in physicochemical methods of characterization. CONCLUSION: This review will discuss recent achievements in PEGylation processes with an emphasis on novel PEG-drugs constructs, the unrealized potential of PEGylation for non-injected routes of delivery, and also on PEGylated versions of polymeric nanoparticles, including dendrimers and liposomes.