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Diversify and conquer: How effector diversity is shaped by host–microbe co-evolution

2026/01/23 by Marion C. Müller, Sabine Brumm, Yiheng Hu +3 · 1 voice · 2 citations
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · Social Sciences · #Biological evolution #Diversity (politics) #Effector #Evolution and Genetic Dynamics #Evolutionary Game Theory and Cooperation #Plant-Microbe Interactions and Immunity #Vertebrate

paper · pdf · doi:10.1371/journal.ppat.1013870

published in PLoS Pathogens 22(1), e1013870 (Public Library of Science)

openalex publication_date 2026/01/23 · openalex created_date 2026/01/24 · openalex updated_date 2026/08/05

Abstract

Effectors are diverse molecules produced and secreted by plant pathogens to facilitate infection often by exerting an "effect" on their host.The production of effector molecules is a ubiquitous feature of plant pathogens.Because many effector proteins act on host targets and are subject of host immune detection, the corresponding effector genes co-evolve with the corresponding host genes involved in immunity or susceptibility.This co-evolution results in diversity at effector loci, both within and between lineages/species.Here, we examine the diverse patterns and consequences of variation observed across the sequence and regulatory landscapes of effector genes and summarize the genomic mechanisms that create them.

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