Catalytic Enantioselective Decarboxylative Mannich-Type Reaction ofN-Unprotected Isatin-Derived Ketimines

2018/08/14 by Masanao Sawa, Shotaro Miyazaki, Ryohei Yonesaki +2 · 1 citation
Chemistry · #Asymmetric Synthesis and Catalysis #Synthesis and Catalytic Reactions #Synthetic Organic Chemistry Methods

paper · doi:10.1021/acs.orglett.8b02306

openalex publication_date 2018/08/14 · openalex created_date 2018/08/22 · openalex updated_date 2026/07/30

Abstract

The first catalytic enantioselective decarboxylative Mannich-type reaction of N-unprotected ketimines is reported, directly providing N-unprotected 3-tetrasubstituted 3-aminooxindoles in high yield and ee without protection/deprotection steps. The utility of this reaction is demonstrated in the short step synthesis of (+)-AG-041R.

Citations

• Direct Access to N‐Unprotected α‐ and/or β‐Tetrasubstituted Amino Acid Esters via Direct Catalytic Mannich‐Type Reactions Using N‐Unprotected Trifluoromethyl Ketimines

Cited by

• Ketimine Mannich reaction [wikipedia]

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