The hallmarks of protein and amino acid restriction in aging and longevity

2026/07/01 by Bailey A. Knopf, Dudley W. Lamming · 1 voice
Biochemistry, Genetics and Molecular Biology · #Amino Acid Enzymes and Metabolism #Genetics, Aging, and Longevity in Model Organisms #Muscle metabolism and nutrition

paper · doi:10.1016/j.cpblue.2026.100079

crossref issued 2026/07/01 · crossref published 2026/07/01 · crossref published-print 2026/07/01 · openalex publication_date 2026/07/01 · crossref created 2026/07/31 · openalex created_date 2026/08/01 · openalex updated_date 2026/08/02 · crossref deposited 2026/08/02 · crossref indexed 2026/08/02

Citations

• Patho-physiologic findings after chronic tryptophan deficiency in rats: A model for delayed growth and aging
• The effect of low protein-high dextrin diet and subsequent food restriction upon life prolongation in Fischer 344 male rats
• Functional impact of high protein intake on healthy elderly people
• The role of protein in weight loss and maintenance
• FGF21 is an endocrine signal of protein restriction
• Arginine metabolism: nitric oxide and beyond
• Hallmarks of Cellular Senescence
• Regulation of metabolic health by dietary histidine in mice
• Hallmarks of aging: An expanding universe
• Loss of epigenetic information as a cause of mammalian aging
• Higher dietary protein intake is associated with sarcopenia in older British twins
• Spatial and functional separation of mTORC1 signalling in response to different amino acid sources
• Cysteine depletion triggers adipose tissue thermogenesis and weight loss
• FGF21 promotes longevity in diet-induced obesity through metabolic benefits independent of growth suppression
• The role of phenylalanine and tyrosine in longevity: a cohort and Mendelian randomization study
• Gut microbiota-derived isovaleric acid alleviates atrial fibrillation by suppressing GSDME-dependent pyroptosis
• FGF21 signals through hindbrain neurons to alter food intake and energy expenditure during dietary protein restriction

Discussions

• Despite our craze for protein, research suggests LOW protein diets actually INCREASE life span & IMPROVE many health markers. In general, calorie restriction has been consistently proven to increase l [bsky, 0 points, 0 comments]