2019/07/31 by Pengfei Xu, Chiara Ianes, Fabian Gärtner +6 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Protein Kinase Regulation and GTPase Signaling #Hippo pathway signaling and YAP/TAZ #Cancer-related Molecular Pathways
paper · pdf · doi:10.1016/j.gene.2019.144005
openalex publication_date 2019/07/31 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Members of the highly conserved pleiotropic CK1 family of serine/threonine-specific kinases are tightly regulated in the cell and play crucial regulatory roles in multiple cellular processes from protozoa to human. Since their dysregulation as well as mutations within their coding regions contribute to the development of various different pathologies, including cancer and neurodegenerative diseases, they have become interesting new drug targets within the last decade. However, to develop optimized CK1 isoform-specific therapeutics in personalized therapy concepts, a detailed knowledge of the regulation and functions of the different CK1 isoforms, their various splice variants and orthologs is mandatory. In this review we will focus on the stress-induced CK1 isoform delta (CK1δ), thereby addressing its regulation, physiological functions, the consequences of its deregulation for the development and progression of diseases, and its potential as therapeutic drug target.