2021/06/08 by Halleh B. Balch, Allister F. McGuire, Jason Horng +7 · 1 citation
Neuroscience · Engineering · #Neuroscience and Neural Engineering #Advanced Memory and Neural Computing #Photoreceptor and optogenetics research
paper · doi:10.1021/acs.nanolett.1c00543
openalex publication_date 2021/06/08 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
The measurement of electrical activity across systems of excitable cells underlies current progress in neuroscience, cardiac pharmacology, and neurotechnology. However, bioelectricity spans orders of magnitude in intensity, space, and time, posing substantial technological challenges. The development of methods permitting network-scale recordings with high spatial resolution remains key to studies of electrogenic cells, emergent networks, and bioelectric computation. Here, we demonstrate single-shot and label-free imaging of extracellular potentials with high resolution across a wide field-of-view. The critically coupled waveguide-amplified graphene electric field (CAGE) sensor leverages the field-sensitive optical transitions in graphene to convert electric potentials into the optical regime. As a proof-of-concept, we use the CAGE sensor to detect native electrical activity from cardiac action potentials with tens-of-microns resolution, simultaneously map the propagation of these potentials at tissue-scale, and monitor their modification by pharmacological agents. This platform is robust, scalable, and compatible with existing microscopy techniques for multimodal correlative imaging.