2006/10/03 by Anatoly B. Kolomeisky · 94 citations
Chemistry · Engineering · Physics and Astronomy · #Asymmetry #Biology #Biophysics #Channel (broadcasting) #Chemical physics #Chemistry #Dynamics (music) #Electrostatics and Colloid Interactions #Force Microscopy Techniques and Applications #Membrane #Molecular dynamics #Molecule #Nanopore and Nanochannel Transport Studies #Particle (ecology) #Physics #Quantum mechanics #cond-mat.soft #cond-mat.stat-mech
paper · pdf · doi:10.1103/physrevlett.98.048105
published in Physical Review Letters 98(4), 048105 (American Physical Society) · 8 pages, 4 figures
arxiv created 2006/10/03 · openalex publication_date 2007/01/26 · arxiv updated 2009/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05
Transport of molecules across membrane channels is investigated theoretically using exactly solvable discrete stochastic site-binding models. It is shown that the interaction potential between molecules and the channel has a strong effect on translocation dynamics. The presence of attractive binding sites in the pore accelerates the particle current for small concentrations outside the membrane, while for large concentrations, surprisingly, repulsive binding sites yield the most optimal transport. In addition, the asymmetry of the interaction potential also strongly influences the channel transport. The mechanism underlying these phenomena is discussed using the details of particle dynamics at the binding sites.