1976/01/01 by James H. Babler, Michael J. Coghlan · 1 citation
Biochemistry, Genetics and Molecular Biology · Chemistry · #Aldehyde #Allylic rearrangement #Aqueous medium #Aqueous solution #Asymmetric Synthesis and Catalysis #Boll weevil #Catalysis #Chemical Synthesis and Analysis #Chemistry #Hydrolysis #Isomerization #Organic chemistry #Synthetic Organic Chemistry Methods
paper · doi:10.1080/00397917608082626
openalex publication_date 1976/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29
The acid-catalyzed isomerization of tertiary vinyl carbinols (2) to the corresponding primary allylic alcohols (5) has been reported numerous times in the chemical literature.1 In addition, the corresponding acetylenic carbinols (3) have been shown2 to rearrange to α,β-unsaturated aldehydes (6) when treated with aqueous acid. Since yields are generally low under the conditions required for the latter transformation, a better method3 involves the isomerization of the corresponding tertiary acetylenic acetate (4) in the presence of silver ion to an allenic acetate, followed by hydrolysis to the desired α,β-unsaturated aldehyde (6).