2004/02/29 by Daniel L. Marks, Claudio Vinegoni, Jeremy S. Bredfeldt +1 · 1 citation
Biochemistry, Genetics and Molecular Biology · Engineering · Physics and Astronomy · #Combustion and flame dynamics #Spectroscopy Techniques in Biomedical and Chemical Research #Spectroscopy and Quantum Chemical Studies #physics.gen-ph #physics.optics
paper · pdf · doi:10.1063/1.1829162
8 pages, 4 figures
arxiv created 2004/02/29 · openalex publication_date 2004/12/06 · arxiv updated 2009/12/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/28
A major impediment to the use of coherent anti-Stokes Raman scattering (CARS) to identify biological molecules is that the illumination levels required to produce a measurable signal often also produce significant nonresonant background from the medium, especially from water. We present a method of nonlinear interferometry to differentiate between which components of the anti-Stokes signal are resonant and nonresonant. The technique takes advantage of the persistence of intermediate states involved in the resonant process. This method is applicable to most existing pulsed CARS illumination methods and provides for identification of resonant CARS. We demonstrate the method by examining the signals produced by acetone, which exhibits resonance, and water, which does not.