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A shear cell study on oral and inhalation grade lactose powders

2025/08/22 by Cavalli, Giulio, Bosi, Roberto, Ghiretti, Alessandro +3
#Applied Physics (physics.app-ph) #FOS: Physical sciences #Soft Condensed Matter (cond-mat.soft)

paper · doi:10.48550/arxiv.2508.16786

Abstract

Shear cell tests have been conducted on twenty different lactose powders, most of which commercially available for oral or inhalation purposes, spanning a wide range of particle sizes, particle morphologies, production processes. The aims of the investigation were: i) to verify the reliability of the technique in evaluating and classifying the flowability of powders; ii) to understand the connection between the flowability of a powder and the morphological properties of its particles; iii) to find a general mathematical relationship able to predict the yield locus shape given the particle size, shape and consolidation state of a lactose powder. These aspects and their limitations are detailed in the manuscript together with other interesting findings on the stick-slip behavior observed in most of the lactose powders examined.

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