2003/03/31 by D. A. Head, David Head, Alex J. Levine +2 · 2 citations
Biochemistry, Genetics and Molecular Biology · Mathematics · Physics and Astronomy · #Artificial intelligence #Biology #Cell #Cellular Mechanics and Interactions #Classical mechanics #Composite material #Computer science #Connection (principal bundle) #Crossover #Cytoskeleton #Deformation (meteorology) #Geometry #Materials science #Mathematics #Mechanics #Microtubule and mitosis dynamics #Physics #Protein Structure and Dynamics #Protein filament #Rigidity (electromagnetism) #cond-mat.dis-nn #q-bio.BM
paper · pdf · doi:10.1103/physrevlett.91.108102
Typos fixed and some technical details clarified. To appear in Phys. Rev. Lett
arxiv created 2003/06/23 · openalex publication_date 2003/09/05 · arxiv updated 2009/11/30 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05
Networks of filamentous proteins play a crucial role in cell mechanics. These cytoskeletal networks, together with various cross-linking and other associated proteins largely determine the (visco)elastic response of cells. In this Letter we study a model system of cross-linked, stiff filaments in order to explore the connection between the microstructure under strain and the macroscopic response of cytoskeletal networks. We find two distinct regimes as a function primarily of cross-link density and filament rigidity: one characterized by affine deformation and one by nonaffine deformation. We characterize the crossover between these two.