2003/01/10 by Pierre Sens, P. Sens, Matthew S. Turner +1 · 6 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Physics and Astronomy · #Caveolin-1 and cellular processes #Erythrocyte Function and Pathophysiology #Lipid Membrane Structure and Behavior #cond-mat.soft #cond-mat.stat-mech #q-bio
paper · pdf · doi:10.1016/s0006-3495(04)74266-6
18 pages, 3 figures
arxiv created 2003/01/10 · openalex publication_date 2004/04/01 · arxiv updated 2009/11/30 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
We study a physical model for the formation of bud-like invaginations on fluid membranes under tension, and apply this model to caveolae formation. We demonstrate that budding can be driven by membrane-bound inclusions (proteins) provided that they exert asymmetric forces on the membrane that give rise to bending moments. In particular, Caveolae formation may not necessarily require forces to be applied by the cytoskeleton. Our theoretical model is able to explain several features observed experimentally in caveolae, where proteins in the caveolin family are known to play a crucial role in the formation of caveolae buds. These include (i) the formation of caveolae buds with sizes in the 100nm range (ii) that a fairly large variation of bud shape is expected (iii) that certain N and C termini deletion mutants result in vesicles that are an order of magnitude larger. Finally, we discuss the possible origin of the morphological striations that are observed on the surfaces of the caveolae.