2021/02/06 by Sophie Knox, Niamh M. O’Boyle · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Advancements in Transdermal Drug Delivery #Dermatology and Skin Diseases #Lipid Membrane Structure and Behavior
paper · pdf · doi:10.1016/j.chemphyslip.2021.105055
openalex publication_date 2021/02/06 · crossref created 2021/02/06 · crossref issued 2021/05/01 · crossref published 2021/05/01 · crossref published-print 2021/05/01 · crossref deposited 2025/09/14 · openalex created_date 2025/10/10 · crossref indexed 2026/07/30 · openalex updated_date 2026/08/03
Our skin is the interface between us and our environment - a flexible barrier that has evolved for protection, immunity, regulation and sensation. Once regarded as inert, we now know that it is a dynamic environment. Skin lipids are crucial to the structure and function of skin. From deep in the hypodermis, through the ceramide-rich epidermis, to the lipids of the skin surface, there are a vast array of different lipids with important roles to play. This review firstly discusses the lipid composition of human skin and secondly, changes that have been found in skin lipid composition in different skin diseases. Further research into skin lipids facilitated by ever-improving methodologies will no doubt generate new knowledge, paving the way for diagnosis, prevention and treatment of skin disorders and diseases.