2001/08/21 by Y. Kafri, D. Mukamel, L. Peliti · 1 citation
Biochemistry, Genetics and Molecular Biology · Chemistry · Materials Science · Physics and Astronomy · #Advanced Physical and Chemical Molecular Interactions #DNA and Nucleic Acid Chemistry #Material Dynamics and Properties #cond-mat.soft #cond-mat.stat-mech #q-bio
paper · pdf · doi:10.1140/epjb/e20020138
published as European Physical Journal B 27, 135 (2002). · 12pages,8 figures, REVTEX4
arxiv created 2001/08/21 · openalex publication_date 2002/05/01 · arxiv updated 2009/11/30 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/28
Experimental studies of the thermal denaturation of DNA yield a strong indication that the transition is first order. This transition has been theoretically studied since the early sixties, mostly within an approach in which the microscopic configurations of a DNA molecule are given by an alternating sequence of non-interacting bound segments and denaturated loops. Studies of these models neglect the repulsive, self-avoiding, interaction between different loops and segments and have invariably yielded continuous denaturation transitions. In this study we exploit recent results on scaling properties of polymer networks of arbitrary topology in order to take into account the excluded-volume interaction between denaturated loops and the rest of the chain. We thus obtain a first-order phase transition in d=2 dimensions and above, in agreement with experiments. We also consider within our approach the unzipping transition, which takes place when the two DNA strands are pulled apart by an external force acting on one end. We find that the unzipping transition is also first order. Although the denaturation and unzipping transitions are thermodynamically first order, they do exhibit critical fluctuations in some of their properties. For instance, the loop size distribution decays algebraically at the transition and the length of the denaturated end segment diverges as the transition is approached. We evaluate these critical properties within our approach.