2001/08/13 by Alexander K. Hartmann · 1 citation
Biochemistry, Genetics and Molecular Biology · Physics and Astronomy · #Fractal and DNA sequence analysis #Genomics and Phylogenetic Studies #Protein Structure and Dynamics #cond-mat.dis-nn #q-bio
paper · pdf · doi:10.1103/physreve.65.056102
published as Phys. Rev. E 65, 056102 (2002) · 5 pages, 4 figures, revtex
arxiv created 2001/08/13 · openalex publication_date 2002/04/15 · arxiv updated 2009/11/30 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
A method to calculate probability distributions in regions where the events are very unlikely (e.g., p approximately 10(-40)) is presented. The basic idea is to map the underlying model on a physical system. The system is simulated at a low temperature, such that preferably configurations with originally low probabilities are generated. Since the distribution of such a physical system is known, the original unbiased distribution can be obtained. As an application, local alignment of protein sequences is studied. The deviation of the distribution p(S) of optimum scores from the extreme-value distribution is quantified. This deviation decreases with growing sequence length.