2000/06/01 by Jun Wang, Wei Wang
Biochemistry, Genetics and Molecular Biology · Physics and Astronomy · #Biochemical and Structural Characterization #Chemical Synthesis and Analysis #RNA and protein synthesis mechanisms #physics.bio-ph #q-bio
paper · pdf · doi:10.1103/physreve.61.6981
published as Phys. Rev. E Vol.61, No.6, 6981-6986 (June 2000) · 6 pages with 4 figures
openalex publication_date 2000/06/01 · arxiv created 2000/06/23 · arxiv updated 2009/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
The folding characteristics of sequences reduced with a possibly simplified representation of five types of residues are shown to be similar to their original ones with the natural set of residues (20 types or 20 letters). The reduced sequences have a good foldability and fold to the same native structure of their optimized original ones. A large ground state gap for the native structure shows the thermodynamic stability of the reduced sequences. The general validity of such a five-letter reduction is further studied via the correlation between the reduced sequences and the original ones. As a comparison, a reduction with two letters is found not to reproduce the native structure of the original sequences due to its homopolymeric features.