2020/01/01 by Steven P. Harvey, Leslie R. McMahon, Frederic J. Berg · 4 citations
Agricultural and Biological Sciences · Immunology and Microbiology · #Pesticide Exposure and Toxicity #Insect and Pesticide Research #Toxin Mechanisms and Immunotoxins
paper · pdf · doi:10.1016/j.heliyon.2019.e03153
openalex publication_date 2020/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29
Several parameters of the Novichok nerve agents A230, A232 and A234 were determined. Hydrolysis rates were approximately one to three orders of magnitude slower than G-type nerve agents and approximately zero to two orders of magnitude slower than V-type nerve agents. A230 was the most labile Novichok compound followed by A232 then A234. Activation energies (E a ) and frequency factors (A) were determined for all three compounds. The organophosphorus acid anhydrolase (OPAA) enzyme had catalytic efficiencies on the Novichok compounds ranging between 10 4 and 10 5 M −1 min −1 with the highest k cat /K m value for A230, then A232 and lastly, A234.