ShK toxin: history, structure and therapeutic applications for autoimmune diseases

2018/06/01 by Shih Chieh Chang, Saumya Bajaj, K. George Chandy · 1 citation
Biochemistry, Genetics and Molecular Biology · Earth and Planetary Sciences · #Nicotinic Acetylcholine Receptors Study #Marine Invertebrate Physiology and Ecology #Marine Sponges and Natural Products

paper · doi:10.15347/wjs/2018.003

openalex publication_date 2018/06/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Abstract

Stichodactyla toxin (ShK) is a 35-residue basic peptide from the sea anemone 'Stichodactyla helianthus' that blocks a number of potassium channels. An analogue of ShK called ShK-186 or Dalazatide is in human trials as a therapeutic for autoimmune diseases.

Cited by

• Stichodactyla toxin [wikipedia]

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