RIG-I like receptors

2019/01/01 by Natalie A. Borg · 1 citation
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Biology #Cytokine Signaling Pathways and Interactions #Genetics #Inflammasome and immune disorders #Receptor #interferon and immune responses

paper · pdf · doi:10.15347/wjs/2019.001

openalex publication_date 2019/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2025/11/06

Abstract

RIG-I (retinoic-acid inducible gene I, also known as DDX58) is the best characterized receptor within the RIG-I like receptor (RLR) family. Together with MDA5 (melanoma differentiation-associated 5) and LGP2 (laboratory of genetics and physiology 2), this family of cytoplasmic pattern recognition receptors (PRRs) are sentinels for intracellular viral RNA that is a product of viral infection. The RLR receptors provide frontline defence against viral infections in most tissues.

Citations

• 5'-Triphosphate RNA Is the Ligand for RIG-I
• Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus
• Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

Cited by

• RIG-I-like receptor [wikipedia]

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