2002/03/09 by Lisa Nogle, William H. Gerwick · 1 citation
Biochemistry, Genetics and Molecular Biology · Environmental Science · Energy · #Marine Sponges and Natural Products #Marine Toxins and Detection Methods #Algal biology and biofuel production
paper · doi:10.1021/ol017275j
openalex publication_date 2002/03/09 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
[reaction: see text] Bioassay-guided investigation of the extract from a Lyngbya majuscula/Schizothrix sp. assemblage of marine cyanobacteria led to the discovery of somocystinamide A (1), an extraordinary disulfide dimer of mixed PKS/NRPS biosynthetic origin. Somocystinamide A (1) was highly acid-sensitive, rapidly and completely converting to a characterizable derivative (2). Compound 1 exhibits significant cytotoxicity against mouse neuro-2a neuroblastoma cells (IC50 = 1.4 microg/mL), whereas 2 has no activity.