2014/08/27 by Melissa Grazielle Morais, Guilherme Augusto Ferreira da Costa, Álan Alex Aleixo +5 · 2 citations
Agricultural and Biological Sciences · Medicine · Biochemistry, Genetics and Molecular Biology · #Essential Oils and Antimicrobial Activity #Phytochemicals and Antioxidant Activities #Plant biochemistry and biosynthesis
paper · doi:10.1080/14786419.2014.951930
openalex publication_date 2014/08/27 · openalex created_date 2016/06/24 · openalex updated_date 2026/04/16
Ethanol extract (EE) and fractions obtained from the ripe fruits of Solanum lycocarpum were examined in order to determine their phenolic composition, antioxidant capacity, antibacterial activities and cytotoxic potential. High-performance liquid chromatography coupled with DAD analysis indicated that caffeic and chlorogenic acids were the main phenolic compounds present in the EE, dichloromethane (DCM) and ethyl acetate (Ac) fractions. The antioxidant activity assessed by the scavenging ability on 1,1-diphenyl-2-picrylhydrazyl radical was significantly more pronounced for DCM and Ac fractions than that of the commercial antioxidant 2,6-di-tert-butyl-4-methylphenol (BHT). EE and fractions exhibited selective antibacterial activity against Gram-positive bacteria, especially the hexane (Hex) and DCM fractions. EE and fractions exhibited low toxicity towards the LLC-MK2 cell line, especially the Hex, DCM and Ac fractions. This work provides the knowledge of phenolic composition in the extract and fractions from the ripe fruits of S. lycocarpum and their antioxidant, antibacterial and cytotoxic activities.