Testing the Markov condition in ion channel recordings

1997/03/01 by Jens Timmer, J. Timmer, S. Klein +1 · 1 citation
Chemistry · Computer Science · Engineering · Physics and Astronomy · #Fault Detection and Control Systems #Mass Spectrometry Techniques and Applications #Target Tracking and Data Fusion in Sensor Networks #chao-dyn #nlin.CD

paper · pdf · doi:10.1103/physreve.55.3306

to appear in Phys. Rev. E

openalex publication_date 1997/03/01 · arxiv created 1997/03/04 · arxiv updated 2009/11/30 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

A statistical test is presented to decide whether data are adequately described by probabilistic functions of finite state Markov chains (``hidden Markov models'') as applied in the analysis of ion channel data. Particularly, the test can be used to decide whether a system obeys the Markov condition. Simulation studies are performed in order to investigate the sensitivity of the proposed test against violations of the model assumptions. The test can be applied analogously to Markov models.

Citations

• Statistical Inference for Probabilistic Functions of Finite State Markov Chains
• A Maximization Technique Occurring in the Statistical Analysis of Probabilistic Functions of Markov Chains

Cited by

• Correlation studies of open and closed state fluctuations in an ion channel: Analysis of ion current through a large-conductance locust potassium channel