2005/11/01 by David Avnir, Thibaud Coradin, Ovadia Lev +1 · 1 citation
Materials Science · Biochemistry, Genetics and Molecular Biology · #Diatoms and Algae Research #Advanced Nanomaterials in Catalysis #Advanced biosensing and bioanalysis techniques
paper · doi:10.1039/b512706h
openalex publication_date 2005/11/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/22
This review is devoted to the most recent developments (2000–2005) of sol–gel materials at the interface with biology. In the context of bioencapsulation in mineral hosts, novel synthetic approaches have been designed, allowing the immobilization of numerous proteins, enzymes and immune molecules as well as poly-saccharides, phospholipids and nucleic acids. These efforts have led to the development of new biosensors and bioreactors. A similar trend was also observed for whole cell encapsulation, survival periods over several weeks now being achieved. This has opened the possibility of designing hybrid hosts for cell-based biosensing and bioproduction, ultimately allowing the development of artificial organs. Indeed, applications of sol–gel processes are not restricted to bioencapsulation, as demonstrated by recent progress in drug release systems and bioactive materials. Finally, the considerable efforts devoted to the biomimetic elaboration of mineral structures suggest that they might be the key for future development of improved sol–gel materials for bio-applications.