2018/03/01 by Alfonso Martínez Arias, Benjamin Steventon · 1 citation
Biochemistry, Genetics and Molecular Biology · #Developmental Biology and Gene Regulation #Pluripotent Stem Cells Research #RNA Research and Splicing
paper · pdf · doi:10.1242/dev.159525
openalex publication_date 2018/03/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Organizers, which comprise groups of cells with the ability to instruct adjacent cells into specific states, represent a key principle in developmental biology. The concept was first introduced by Spemann and Mangold, who showed that there is a cellular population in the newt embryo that elicits the development of a secondary axis from adjacent cells. Similar experiments in chicken and rabbit embryos subsequently revealed groups of cells with similar instructive potential. In birds and mammals, organizer activity is often associated with a structure known as the node, which has thus been considered a functional homologue of Spemann's organizer. Here, we take an in-depth look at the structure and function of organizers across species and note that, whereas the amphibian organizer is a contingent collection of elements, each performing a specific function, the elements of organizers in other species are dispersed in time and space. This observation urges us to reconsider the universality and meaning of the organizer concept.