2009/04/03 by Ali Naji, Paul J. Atzberger, Frank L. H. Brown
Biochemistry, Genetics and Molecular Biology · Engineering · Physics and Astronomy · #Lipid Membrane Structure and Behavior #Nanopore and Nanochannel Transport Studies #Protein Structure and Dynamics #cond-mat.soft #cond-mat.stat-mech
paper · pdf · doi:10.1103/physrevlett.102.138102
published as Phys. Rev. Lett. 102, 138102 (2009) · 4 pages, 2 figures
openalex publication_date 2009/04/03 · arxiv created 2009/05/23 · arxiv updated 2009/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
We introduce a simulation strategy to consistently couple continuum biomembrane dynamics to the motion of discrete biological macromolecules residing within or on the membrane. The methodology is used to study the diffusion of integral membrane proteins that impart a curvature on the bilayer surrounding them. Such proteins exhibit a substantial reduction in diffusion coefficient relative to "flat" proteins; this effect is explained by elementary hydrodynamic considerations.