2013/06/17 by Barbara Gandolfi, Hasan Alhaddad, Shannon E K Joslin +4 · 2 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Allele #Biology #Breed #CATS #Coat #Evolutionary biology #Gene #Genetics #Hair Growth and Disorders #Haplotype #Medicine #Paleontology #Skin and Cellular Biology Research #Wnt/β-catenin signaling in development and cancer
paper · pdf · doi:10.1038/srep02000
openalex publication_date 2013/06/17 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
One of the salient features of the domestic cat is the aesthetics of its fur. The Selkirk Rex breed is defined by an autosomal dominant woolly rexoid hair (ADWH) abnormality that is characterized by tightly curled hair shafts. A genome-wide case - control association study was conducted using 9 curly coated Selkirk Rex and 29 controls, including straight-coated Selkirk Rex, British Shorthair and Persian, to localize the Selkirk autosomal dominant rexoid locus (SADRE). Although the control cats were from different breed lineages, they share recent breeding histories and were validated as controls by Bayesian clustering, multi-dimensional scaling and genomic inflation. A significant association was found on cat chromosome B4 (Praw = 2.87 × 10(-11)), and a unique haplotype spanning ~600 Kb was found in all the curly coated cats. Direct sequencing of four candidate genes revealed a splice site variant within the KRT71 gene associated with the hair abnormality in Selkirk Rex.