Multiple sclerosis pathogenesis: missing pieces of an old puzzle

2018/06/08 by Reza Rahmanzadeh, Wolfgang Brück, Alireza Minagar +1 · 1 citation
Medicine · #Multiple Sclerosis Research Studies #Systemic Lupus Erythematosus Research #Peripheral Neuropathies and Disorders

paper · doi:10.1515/revneuro-2018-0002

openalex publication_date 2018/06/08 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/22

Abstract

Traditionally, multiple sclerosis (MS) was considered to be a CD4 T cell-mediated CNS autoimmunity, compatible with experimental autoimmune encephalitis model, which can be characterized by focal lesions in the white matter. However, studies of recent decades revealed several missing pieces of MS puzzle and showed that MS pathogenesis is more complex than the traditional view and may include the following: a primary degenerative process (e.g. oligodendroglial pathology), generalized abnormality of normal-appearing brain tissue, pronounced gray matter pathology, involvement of innate immunity, and CD8 T cells and B cells. Here, we review these findings and discuss their implications in MS pathogenesis.

Citations

• Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy?
• Localizing central nervous system immune surveillance: Meningeal antigen‐presenting cells activate T cells during experimental autoimmune encephalomyelitis
• Caspase-Dependent and Caspase-Independent Oligodendrocyte Death Mediated by AMPA and Kainate Receptors
• How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis

Cited by

• Experimental autoimmune encephalomyelitis [wikipedia]

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